Dr Mavuto Mukaka Staff Profile

Senior Lecturer in Biostatistics

PhD. (UK), MSc. (Australia), BSc. (UNIMA)
mmukaka@gmail.com   

Dr. Mavuto Mukaka received his university education from University of Liverpool, United Kingdom; Macquarie University, Australia; and Chancellor College, University of Malawi. He did his postdoctoral research in Biostatistics at the Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University (USA). 

He has the experience in lecturing courses like Clinical Trials, Longitudinal Data Analysis, Survival analysis, and Discrete Data Analysis to students in the Masters in Biostatistics programme at Chancellor College since first intake in 2010.

He has supervised students at both MSc and PhD levels. Dr. Mavuto Mukaka has successfully supervised masters theses of 8 students in the Masters in Biostatistics programme at Chancellor College; Louis Banda, Madalitso Tolani, Andrew Kumitawa, Christopher Stanley, Rabson Dzinza, Halima Twabi, Mafase Ng’ong’ola Sesani, and Vincent Samuel who have since graduated from the programme. He is currently supervising 5 more students in the programme.

He has more than 50 publications to his name in peer reviewed statistical methodology and biomedical science journals. His current research interests focuses on the Design and Analysis of Cluster Randomized Trials and Statistical Methods of Handling Missing Data with applications in Clinical Trials. 

Dr. Mavuto Mukaka is currently working in the Nuffield Department of Medicine, University of Oxford (UK). He is the Head of Statistics and a senior researcher at the Mahidol-Oxford Tropical Research Unit, Mahidol University, Bangkok in Thailand. He is also a an honorary Senior Lecturer in Biostatistics at the College of Medicine, University of Malawi where he also supervised Masters in Public Health students research and a PhD student. Dr. Mukaka has been actively involved in a variety of advisory committees including Data and Safety Monitoring Boards (DSMBs) as a Trial Statistician. He has also been a member of Malawi’s regulatory authority (the Malawi Pharmacy Medicines and Poisons Board) responsible for statistical review of study protocols. He is also a reviewer in international biomedical science journals.

RECENT PEER-REVIEWED PUBLICATIONS

 1.      Keene CM,  Dondorp A,  Crawley J,  Eric O Ohuma EO Mukaka M*. A Competing-Risk Approach to Modelling Length of Stay in Severe Malaria Patients in South-East Asia and the Implications for Planning of Hospital Services. Clinical Infectious Diseases,, https://doi.org/10.1093/cid/ciy211

2.      Twabi HS, Mukaka M*. Modelling Length of Hospital Stay for Tuberculosis Treated in-Patients at Queen Elizabeth Central Hospital: a Competing Risk Perspective. Open Acc Biostat Bioinform. 1(2). OABB.000507. 2018.

3.      Tripura R, Peto TJ, ..,  Mukaka M, ..., Dondorp AM. A Controlled Trial of Mass Drug Administration to Interrupt Transmission of Multi Drug Resistant Falciparum Malaria in Cambodian Villages. Clinical Infectious Diseases. 2018, https://doi.org/10.1093/cid/ciy196

4.      Wangrangsimakul T, Althaus T, Mukaka M, et al. Causes of acute undifferentiated fever and the utility of biomarkers in Chiangrai, northern Thailand. PLoS Neglected Tropical Diseases 2018  (In Press)

5.      Burns R, .. Mukaka M, …. Blacksel SD. Serosurveillance of Coxiellosis (Q-fever) and Brucellosis in goats in selected provinces of Lao People’s Democratic Republic. PLOS Neglected Tropical  Diseases. 2018 (In Press)

6.    Saraswati K, Day NPJ, Mukaka M, Blacksell, SD. Scrub typhus point-of-care testing: a systematic review and meta-analysis. PLOS Neglected Tropical  Diseases. 2018 (https://doi.org/10.1371/journal.pntd.0006330)

7.   Hantrakun V, Thaipadungpanit J, Rongkard P, Srilohasin P, Amornchai P, Langla S, Mukaka M, Chantratita N, Wuthiekanun V, Dance DAB, Day NPJ, Peacock SJ, Limmathurotsakul D. Presence of B. thailandensis and B. thailandensis expressing B. pseudomallei-like capsular polysaccharide in Thailand, and their associations with serological response to B. pseudomallei. PLoS Negl Trop Dis. 2018.  12(1):e0006193. https://doi.org/10.1371/journal.pntd.0006193.

8.   Taylor WR, Khu H, Maitland K, …., Mukaka M*. Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria – a proposed model-derived age-based regimen for sub-Saharan Africa. BMC Medicine (2018) 16:11 DOI 10.1186/s12916-017-0990-6

9.   Nguyen T, von Seidlein L, Thu PNH, g Hung NT, Son DH, Tien NT, Dung NV, Quang HH, Mukaka M, Day NPJ, White NJ, Dondorp AM, Tran TH. The persistence and oscillations of submicroscopic Plasmodium falciparum and vivax infections over time in Vietnam: findings from a nested cohort study. The Lancet Infect Dis 2018. http://dx.doi.org/10.1016/ S1473-3099(18)30046-X

 10.  Mukaka M*, White SA, Mwapasa V, Kalilani-Phiri L, Terlouw DJ. Faragher EB..Adjusted risk difference estimation: an assessment of convergence problems with application to malaria efficacy studies. Open Open Acc Biostat Bioinform. 1(1). OABB.000502. 2017.

 11.  Wall EC, Mukaka M, Denis B, Mlozowa VS , Msukwa M, Kasambala K , Nyrienda M , Allain TJ , Faragher B , Heyderman RS, Lalloo DG. Goal directed therapy for suspected acute bacterial meningitis in adults and adolescents in sub-Saharan Africa. . PLoS ONE 2017 12(10): e0186687.

 12.  Haniffa R, Mukaka M, Munasinghe SB, De Silva AP, Jayasinghe KSA, de Keizer N, DondorpAM. : Simplified prognostic model for critically ill patients in resource limited settings in South Asia. Critical Care. 2017 17;21(1):250.

 13.     Haniffa R, De Silva AP, Weerathunga, Mukaka M, Athapattu P, Munasinghe S, Mahesh B,Mahipala P, De Silva, Abayadeera A, Jayasinghe S, de Keizer N, Dondorp AM. Applicability of the APACHE II model to a lower middle income country.  Journal of Critical Care 42 (2017) 178–183

 14.  von Seidlein L, Ikonomedis K, Mshamu S, Nkya TE, Mukaka M, Pell C, Lindsay SW, Deen JL Kisinza WN, Knudsen JB. Affordable house designs to improve health in rural Africa: a field study from northeastern Tanzania. Thelancet planetary health, Vol 1, 2017.

15.   Mbotwa J, Singini I, Mukaka M*.  Discrepancy between statistical analysis method and study design in medical research: Examples, implications, and potential solutions. Malawi Medical Journal 29 (1) 2017.

16  Douangngeun B, Theppangna W, Phommachanh P, Chomdara K, Phiphakhavong S, Khounsy S, Mukaka M, Dance DAB,  Blacksell SD. Rabies surveillance in dogs in Lao PDR from 2010-2016. PLOS Neglected Tropical Diseases. 2017 https://doi.org/10.1371/journal.pntd.0005609

 

 

17  Plewes K, Kingston KWF, Ghose A, Maude RJ, Herdman T, Leopold SJ, Ishioka H, Hasan MU, Haider S, Alam S, Piera KA, Charunwatthana P,Silamut K, Yeo TW, Abul Faiz A, Lee SJ, Mukaka M, PhD; Gareth D.H. Turner GDH, MBBCh PhD; Anstey NM, Roberts II LJ, MD; White NJ, ,Day NPJ, Hossain A, Dondorp AM. Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study. BMC Infectious Diseases. BMC Infect Dis. 2017. 27;17(1):313. doi: 10.1186/s12879-017-2373-1.

 

18  Mzilahowa T, Luka-Banda M , Uzalili V, Mathanga D.P, Campbell Jnr CH, Mukaka M, Gimnig JE. Risk factors for Anopheles spp. mosquitoes in rural and urban areas in Blantyre District, southern Malawi. Malawi Medical Journal 28 (4) 2016.

 

19  Emma C Wall*, Mukaka M*,  Matthew Scarborough , Katherine MA Ajdukiewicz , Katharine E Cartwright FRCPath , Mulinda Nyirenda, Brigitte Denis, Theresa J Allain, Brian Faragher, David G Lalloo, Robert S Heyderman. Prediction of outcome from adult bacterial meningitis in a high HIV seroprevalence, resource-poor setting using the Malawi Adult Meningitis Score (MAMS). CID 2017:64: 413-419.

 

 

20  Leang R, Naw  Khu H, Mukaka M, Debackere M, Tripura R, Soy T K, Chy S, K, Buchy P, Tarantola A, Menard D, Roca-Felterer A, Fairhurst R, Kheng S, Muth S, Ngak S, Dondorp A, White N J, Taylor W

 

21  R J. An optimised age based dosing regimen for single low dose primaquine for transmission blocking in Cambodia. BMC Medicine 2016 Oct 27;14(1):171.

 

 

22  Mukaka M*, White SA, Terlouw DJ, Mwapasa V, Kalilani-Phiri L Faragher EB. Is Using Multiple Imputation (MI) Better Than Complete Case (CC) Analysis For Estimating a Prevalence (Risk) Difference In Randomized Controlled Trials When Binary Outcome Observations Are Missing?  Trials 2016 , 17:341

 

23  Mbale E.W, Moxon C.A, Mukaka M,, Chagomerana M, Glover S, Chisala N, Omar S, Molyneux M, Seydel K, Craig A.G, Taylor T, Heyderman R.S, Mallewa M. HIV coinfection influences the inflammatory response but not the outcome of cerebral malaria in Malawian children. Journal of Infection. 2016 73(3): 189–199.

 

 

24  Mukaka M*, White SA, Mwapasa V, Kalilani-Phiri L, Terlouw DJ and Faragher EB. Model choices to obtain adjusted risk difference estimates from a binomial regression model with convergence problems: An assessment of methods of adjusted risk difference estimation. J Med Stat Inform. 2016; 4:5. http://dx.doi.org/10.7243/2053-  7662-4-5

 

 

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